原料药西多福韦 西多福韦

shanghai sun-sail pharmaceutical science&technology co.ltd

product name:cidofovir

date of report:2009-12-5

cas:149394-66-1

batch no：090331

molecular formula:c8h14n3o6p.2h2o

molecular:315.22

structure：

test items

result

description

white crystalline powder

slightly soluble in water, practically insoluble in methanol, practically insoluble in ethyl acetate.

identification(ir)

conform

chlorides (%)

<0.01

related substance

individual impurities (%) <0.1

0.045

total impurities (%) <0.5

0.105

water（%）

11.20

heavy metals

<10ppm

ph

3.3

[α]d20

-90.8o

assay（on the dried basis）(%)

100.43

residual solvents

(ppm)

solvents

methanol

21.60

ethanol

n.d.

acetone

14.84

ethyl acetate

228.90

tetrahydrofuran

5.30

n,n-dimethylformamide

n.d.

pyridine

n.d.

dichloromethane

6.65

benzene

1.98