| 产品名称 | 食欲肽B (人)(OREXIN B (HUMAN)) CAS: 205640-91-1原料供应发货仅供科研试验 |
|---|---|
| 公司名称 | 南京辰瑞晟生物医药科技有限公司 |
| 价格 | .00/件 |
| 规格参数 | 品牌:CRS 型号:CMO 产地:国产 |
| 公司地址 | 南京市雨花台区安德门大街57号楚翘城5幢503-008室（注册地址） |
| 联系电话 | 0571-87428035 15360676961 |
| 中文名 | 食欲肽B (人) |
| 英文名 | OREXIN B (HUMAN) |
| 别名 | 食欲肽B (人) 人OREXIN B |
| 英文别名 | HYPOCRETIN-2 OREXIN B (HUMAN) HYPOCRETIN-2, HUMAN Orexin B (huMan)Hypocretin-2 (huMan) ARG-SER-GLY-PRO-PRO-GLY-LEU-GLN-GLY-ARG-LEU-GLN-ARG-LEU-LEU-GLN-ALA-SER-GLY-ASN-HIS-ALA-ALA-GLY-ILE-LEU-THR-MET-NH2 |
| CAS | 205640-91-1 |
| 化学式 | C123H212N44O35S |
| 分子量 | 2899.34 |
| 存储条件 | -20°C |
| 体外研究 | Orexin B is derived by proteolytic amino acid precursor, prepro-orexin, which is encoded by a gene localized to chromosome 17q21 in humans. In radioligand binding studies, Orexin B has a higher affinity for the OX2 receptor. Human Orexin B has two amino acid substitutions when compared with the rodent sequence. OX2 receptor is indeed a high-affinity receptor for human orexin B, with an IC 50 of 36 nM in the binding assay and an EC 50 of 60 nM in the [Ca 2+ ]i transient assay. Human Orexin B has significantly lower affinity for the human OX1: the calculated IC 50 in the competitive binding assay and the EC 50 in the [Ca 2+ ]i transient assay are 420 nM and 2500 nM for human orexin-B, respectively. |
| 体内研究 | Human Orexin B significantly augments food intake; at the 2 hr time point, 5- and 12-fold stimulation of food consumption is observed by 3 nM and 30 nM orexin-B, respectively. |