大量提供高品质虎杖提取物白藜芦醇

brief introduction
synonyms---hu zhang, japanese knotweed, giant knotweed

resveratrol (trans-)
chemical name:trans-3,5,4"-trihydroxystilbene;3,4",5-stilbenetriol;(e)-5-(p-hydroxystyryl)resorcinol (e)-5-(4-hydroxystyryl)benzene-1,3-diol
molecular formula:c14h12o3
mol. wt.:228.24

molecular structure:

resveratrol (3,5,4"-trihydroxystilbene) is a polyphenolic phytoalexin. it is a stilbenoid, a derivate of stilbene, and is produced in plants with the help of the enzyme stilbene synthase. it exists as two geometric isomers: cis- (z) and trans- (e), with the trans-isomer shown in the top image. the trans- form can undergo isomerisation to the cis- form when exposed to ultraviolet irradiation. trans-resveratrol in the powder form was found to be stable under "accelerated stability" conditions of 75% humidity and 40 degrees c in the presence of air. resveratrol content also stayed stable in the skins of grapes and pomace taken after fermentation and stored for a long period.

acetyl-resveratrol
cas no.: 42206-94-0
chemical name: 5-[(1e)-2-[4-(acetyloxy)phenyl]ethenyl]-1,3-benzenediol diacetate; 3,4",5-triacetoxy-trans-stilbene; 3,5,4"-tri-o-acetylresveratrol; trans-resveratrol triacetate
molecular formula: c20h18o6
mol. wt.: 354.35

molecular structure:

acetyl-resveratrol is a derivative of the resveratrol (trans-). the resveratrol’s hydroxyls are replaced by acetyls. acetyl –resveratrol is called prodrug on medicinal chemistry. acetyl-resveratrol is more stable than trans-resveratrol. when absorbed, it returns to resveratrol under action of metabolism. scientists have started analyzing these naturally occurring analogs to determine why it is they seem to be so biologically active and important. what they found was that among these analogs, acetylated phenolics exhibited a higher level of activity that is attributed to faster absorption and greater cellular uptake. the existence of these acetylated phenolic compounds in natural sources has been established in many recent studies and the comparative data is being studied extensively. so far the naturally occurring acetylated derivatives of resveratrol have been identified in plants and specifically, triacetylated resveratrol has been found in marine invertebrates.

benefits
anti-oxidant
life extension
cancer prevention (anti-cancer)
anti-diabetic property (activate ampk, blood sugar lowering)
beneficial cardiovascular effects
anti-inflammatory effects

the mechanisms of resveratrol"s apparent effects on life extension are not fully understood, but they appear to mimic several of the biochemical effects of calorie restriction. resveratrol interferes with all three stages of carcinogenesis — initiation, promotion and progression.

resveratrol was reported effective against neuronal cell dysfunction and cell death, and in theory could help against diseases such as huntington"s disease and alzheimer"s disease.

research indicates that resveratrol has direct inhibitory action on cardiac fibroblasts, and may inhibit the progression of cardiac fibrosis.

research demonstrated that resveratrol increased intracellular glutathione levels via nrf2-dependent upregulation of gamma-glutamylcysteine ligase in lung epithelial cells, which protected them against cigarette smoke extract induced oxidative stress.

dosage
• the typical dose is 500-1200mg per day (usually in 2-3 doses throughout the day).
• consult physicians for different condition specifics.

the most efficient way of administering resveratrol in humans appears to be buccal delivery that is without swallowing, by direct absorption through the inside of the mouth. when one mg of resveratrol in 50 ml solution was retained in the mouth for one min before swallowing, 37 ng/ml of free resveratrol were measured in plasma two minutes later. this level of unchanged resveratrol in blood can only be achieved with 250 mg of resveratrol taken in a pill form.
gni’s resveratrol features and benefits:
resveratrol is one of gni"s most competitive products, with many advantages as list in the following, produced as our patent-pending process and know-how technology from polygonum cuspidatum roots.
• produced with pure water only
• high purity: over 99%
• low emodin content
• no solvent - residual free
• pesticide-free
• crystal white in appearance
• high anti-bacteria, and longer shelf life