专业定制RGD环肽

        近些年，人们对含RGD序列的环肽及其类似物的研究越来越热。RGD序列即含有精氨酰-甘氨酰－天冬氨酸（Arg-Gly-Asp)的三肽序列，该三肽序列是细胞中粘附蛋白的功能序列，Zui初是在细胞外基质（简称ECM）中获得的。在细胞生长过程中正常细胞只有粘附于一定的基质才能生长，脱离了基质细胞生长就会很快停止于Gl期或 G0期。整合素(Integrin)即RGD受体的统称[1]，整合素介导着许多种类的细。细胞及细胞．底物间的相互作用，参与许多生物学过程。如体内平衡调节，细胞粘附，细胞迁移，细胞内信号传递过程，淋巴细胞识别，血小板的凝聚等。含RGD序列的粘附蛋白在细胞粘附中起重要作用[2]。药理学实验表明，许多含RGD序列的小分子片段可抑制细胞的粘附。许多病理学过程如血栓形成，肿瘤组织的转移等都与细胞粘附作用有关。因此RGD类多肽的粘附性成为药物设计的新靶点，含RGD序列的多肽或化合物有望治疗一些与细胞粘附作用相关的疾病。

RGD Arg-Gly-Asp
RGDS Arg-Gly-Asp-Ser
GRGDS Gly-Arg-Gly-Asp-Ser
GRGES H-Gly-Arg-Gly-Glu-Ser-OH
GRGDNP H-Gly-Arg-Gly-Asp-Asn-Pro-OH
c[RADfK(PEG-PEG)] c[Arg-Ala-Asp-d-Phe-Lys(PEG-PEG)] 
c[RGDfK (Ac-SCH2CO)] c[Arg-Gly-Asp-d-Phe-Lys (Ac-SCH2CO)] 
c(RADfC) cyclo (Arg-Ala-Asp-d-Phe-Cys)
c(RADfK) cyclo (Arg-Ala-Asp-d-Phe-Lys)
c(RADfV) cyclo (Arg-Ala-Asp-d-Phe-Val)
c(RADyK) cyclo (Arg-Ala-Asp-d-Tyr-Lys)
c(RGDfC) cyclo (Arg-Gly-Asp-d-Phe-Cys)
c(RGDfE) cyclo (Arg-Gly-Asp-d-Phe-Glu)
c(RGDfK) cyclo (Arg-Gly-Asp-d-Phe-Lys)
c(RGDyC) cyclo (Arg-Gly-Asp-D-Tyr-Cys)
c(RGDyE) cyclo (Arg-Gly-Asp-D-Tyr-Glu)
c(RGEfK) cyclo (Arg-Gly-Glu-d-Phe-Lys)
c[RGDfK(Biotin)] cyclo [Arg-Gly-Asp-d-Phe-Lys(Biotin)]
c[RGDfK(Biotin-PEG-PEG)] cyclo [Arg-Gly-Asp-d-Phe-Lys(Biotin-PEG-PEG)]
HYNIC-RGD cyclo [Arg-Gly-Asp-d-Phe-Lys(HYNIC)]
c(RGDfK(PEG)) cyclo [Arg-Gly-Asp-d-Phe-Lys(PEG)]
DOTA-E-[c(RGDfK)2] DOTA-Glu-[cyclo (Arg-Gly-Asp-d-Phe-Lys)]
E[c(RGDfK)]2 Glu[cyclo (Arg-Gly-Asp-d-Phe-Lys)]2
E[c(RGDyK)]2 Glu[cyclo (Arg-Gly-Asp-d-Tyr-Lys)]2
c(RGDfV) cyclo (Arg-Gly-Asp-d-Phe-Val)